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Resonance light scattering (RLS) detection of nanoparticle separations in a microelectrical field-flow fractionation system

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2 Author(s)
Graff, M. ; Sch. of Electr. & Comput. Eng., Georgia Inst. of Technol., USA ; Bruno Frazier, A.

In this study, resonance light scattering (RLS) is demonstrated as a detection methodology for real-time visualization of the electrical field-flow fractionation process. On-column RLS was used to monitor the fractionation of a bolus sample containing 40-, 60-, and 80-nm-diameter RLS Particles into individual particles and bands of particles. Optical detection using the RLS system was correlated to an on-chip electrical conductivity detector. Particle concentrations as low as 1.08×10-12 M (1 RLS Particle/1.54 pL) were detected using both the optical and electrical detection systems.

Published in:

Nanotechnology, IEEE Transactions on  (Volume:5 ,  Issue: 1 )

Date of Publication:

Jan. 2006

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