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In recent years, information technology has made remarkable advancement and found increasing, applications in various fields. In the medical field, computer is playing a more important role in assisting the disabled. However, the interface between the disabled and a computer is usually composed of push button and touch sensors that are difficult of use. This research aims to develop a more user-friendly wearable interface using a MEMS (micro electro mechanical system) accelerometer and an optical fiber shape sensor that enable the disabled to use a computer more effectively. To demonstrate the application of this wearable interface, we developed several systems including a sensor fusion system for detecting motion of a human body, a communication device for the disabled to control computer keyboards and appliances, and a rehabilitation device referred to as a data glove. The effectiveness of the interface is demonstrated through several field tests.