By Topic

CLUGO: a clustering algorithm for automated functional annotations based on gene ontology

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
In-Yee Lee ; Dept. of Electr. Eng., National Taiwan Univ., Taiwan ; Jan-Ming Ho ; Ming-Syan Chen

We address the issue of providing highly informative and comprehensive annotations using information revealed by the structured vocabularies of gene ontology (GO). For a target, a set of candidate terms for inferring target properties is collected and form a unique distribution on the GO directed acyclic graph (DAG). We propose a novel ontology-based clustering algorithm $CLUGO, which considers GO hierarchical characteristics and the clustering of term distributions. By identifying significant groups in the distributions, CLUGO assigns comprehensive and correct annotations for a target. According to the results of experiments with automated sequence functional annotations, CLUGO represents a considerable improvement over our previous work - GOMIT in terms of recall while maintaining a similar level of precision. We conclude that given a GO candidate term distribution, CLUGO is an efficient ontology-based clustering algorithm for selecting comprehensive and correct annotations.

Published in:

Fifth IEEE International Conference on Data Mining (ICDM'05)

Date of Conference:

27-30 Nov. 2005