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Epilog, a Unix-based real-time operational support system for electroencephalogram (EEG) waveform acquisition, storage, analysis, display, and printing, is described. The system is designed to be used for diagnosis and surgical planning in a large epilepsy program. The implemented system has two monitoring units consisting of four rooms with their associated computer, video, and medical support systems. A central computer hub performs Epilog services for each unit. Each hub acquires and processes up to 256 channels of EEG 24 h per day, and serves as a control center for much of the automation in the unit. The EEG data structures and data flow used in Epilog are discussed.