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In this paper, we present a fully integrated front-end of a portable spectroreflectometry-based brain imaging system dedicated for acquisition of modulated optical signals at a frequency of 1 Hz to 25 kHz. The proposed front-end preamplifier is composed of a photodetector, a transimpedance preamplifier, a two-stage voltage amplifier and a mixer. Strict constraints regarding noise thus have to be considered. The preamplifier consists of a transimpedance block featuring a 95-dBΩ gain and an average input current noise density at the frequency of interest of approximately 3 pA/√Hz. Each of the two subsequent voltage amplifiers allows the user to obtain an additional 25-dB gain. Considering the tuning capabilities and the losses due to the filters and the nonideal buffers, the proposed front-end allows us to obtain a total gain up to 145 dB. The back-end of the amplification chain is composed of a mixer which is used to produce a continuous voltage proportional to the amplitude of the input optical signals. All those features were integrated using CMOS 0.18-μm technology and the experimental results are in agreement with the initial design requirements.