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A novel system-on-a-chip (SoC) test scheme taking inspiration from the human immune system is presented. Such a scheme is based on the negative-selection mechanism which provides the human body with the capability to discriminate between the self (body's own cell) and any foreign cell (non-self). Based on this, it is design a test scheme which is emulated and executed by an embedded processor in order to test other cores of the SoC. Experimental results showing the effectivity of the proposed scheme are presented.