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Intrinsic optical signal imaging of a ratiometric fluorescence oxygen nanosensor

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6 Author(s)
Zhang, G. ; Biomed. Eng. Program, Louisiana Tech. Univ., Ruston, LA, USA ; Shitole, P.S. ; Pujari, R.A. ; Charnani, V.S.
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Several imaging techniques and methods have been developed to map the metabolic or electrical changes during brain functions in high spatial and temporal resolutions. Wide-field intrinsic optical signal (IOS) imaging is an excellent method for its spatial resolution of 50-100 μm and a wide imaging field of several mm2 that cannot be achieved by any microscope. A nano-encapsulated fluorescence dye sensor that is specifically sensitive to oxygen level was fabricated. The fluorescence images of the nanosensor were collected by a wide-field IOS imaging system under two different oxygen concentrations and analyzed by MATLAB software for the nanosensor's oxygen quenching property.

Published in:

Microtechnology in Medicine and Biology, 2005. 3rd IEEE/EMBS Special Topic Conference on

Date of Conference:

12-15 May 2005