System Maintenance:
There may be intermittent impact on performance while updates are in progress. We apologize for the inconvenience.
By Topic

Open environment micro device for integration of patch clamp instrumentation with targeted microfluidic chemical delivery

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

4 Author(s)
Pearce, T.M. ; Dept. of Biomed. Eng., Wisconsin-Madison Univ., Wisconsin, WI, USA ; Oakes, S.G. ; Blake, A.J. ; Williams, J.C.

We describe a technique for the fabrication and use of a microfluidic flow device that has portions that are open to the external environment. Matching inlet and outlet flow rates in the device forms virtual walls through surface tension at the liquid-air interface. Traditional instrumentation, such as the patch-clamp pipette, can be introduced into the flow stream through the surface-tension walls, thereby combining decades of electrophysiology techniques with the benefits of microfluidic environmental control of in-vitro tissue samples such as neural cultures and brain slices.

Published in:

Microtechnology in Medicine and Biology, 2005. 3rd IEEE/EMBS Special Topic Conference on

Date of Conference:

12-15 May 2005