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This paper develops a wearable biomedical health-care system which incorporates the wearable computing technology with multi-agent software architecture to provide a solution to the medical-care problems. The embedded Linux based wearable medical computer connects various sensors which can detect the patients' vital signs, such as electrocardiogram (ECG), body temperature, and body humidity. In order to get more reliable and accurate information, the multi-sensor fusion algorithm is employed to integrate the sensor information. The filter banks based QRS complex and heart beat detection algorithm, and fuzzy fusion algorithms are implemented to construct the diagnosis system of this wearable biomedical computer. Furthermore, the personal nursing agent (PNA) and multi-agent based infrastructure for modern patient information and management system are developed. The experimental results show that this system is helpful and useful for managing and monitoring patients. Accordingly, the wearable biomedical health-care system is regarded as a highly efficient biomedical system and inherits both features of multi-agent architecture and wearable computing, i.e., decentralized, reliable, autonomous, unrestrictive, and cooperative features.