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In this paper we study the end-to-end performance of the enhanced uplink of WCDMA. We present results for latency and TCP performance on both uplink and downlink when using the enhanced uplink. The results show that the enhanced uplink can significantly improve the end-to-end performance of both for up- and downlink oriented traffic when compared to the uplink provided by 3GPP R5. The expected performance depends strongly on the configuration of the enhanced uplink, especially on the HARQ operating point.