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A novel solution is provided for the bias estimation problem in multiple asynchronous sensors using common targets of opportunity. The decoupling between the target state estimation and the sensor bias estimation is achieved without ignoring or approximating the crosscovariance between the state estimate and the bias estimate. The target data reported by the sensors are usually not time-coincident or synchronous due to the different data rates. Since the bias estimation requires time-coincident target data from different sensors, a novel scheme is used to transform the measurements from the different times of the sensors into pseudomeasurements of the sensor biases with additive noises that are zero-mean, white, and with easily calculated covariances. These results allow bias estimation as well as the evaluation of the Cramer-Rao lower bound (CRLB) on the covariance of the bias estimate, i.e., the quantification of the available information about the biases in any scenario. Monte Carlo simulation results show that the new method is statistically efficient, i.e., it meets the CRLB. The use of this technique for scale and sensor location biases in addition to the usual additive biases is also presented.