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We discuss a prefiltering technique for interference mitigation in the downlink of a time division duplex (TDD) multicarrier code-division multiple access (MC-CDMA) system. The base station (BS) is equipped with multiple transmit antennas, and channel state information (CSI) is obtained at the transmitter side by exploiting the channel reciprocity between uplink and downlink transmissions. The prefiltering coefficients are designed so as to minimize a proper cost function that depends on the signal-to-interference-plus-noise ratios (SINRs) at the mobile terminals (MTs). The resulting scheme allows using a simple despreading receiver, thereby eliminating the need for channel estimation and equalization. Numerical results show the advantages of the proposed scheme over some existing solutions.