By Topic

Surface roughness index, a novel approach to compare protein surfaces

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

3 Author(s)
P. V. Varadwaj ; Bioinformatics Div., Indian Inst. of Technol., Allahabad, India ; T. Lahiri ; O. Tsodikov

In course of evolution similar sequences may diverge to change topology of the structure but active sites that are essential to protein function have a possibility to be maintained. Moreover, protein molecules of overall different structures could converge to similar functions by evolutionary development of similar active sites. In such cases, mere sequence based structure comparisons are likely to be inadequate in describing or identifying protein functions and evolutionary relationships among them. In this paper we show the importance of studying the surface roughness of protein to get the holistic information about protein structural similarity profile. Using an invariant coordinate system designed and referred by us as molecular coordinate system we have introduced a new parameter surface roughness index (SRI) to study the protein surface. The possible utility of SRI to explore protein structure is discussed.

Published in:

Proceedings of 2005 International Conference on Intelligent Sensing and Information Processing, 2005.

Date of Conference:

4-7 Jan. 2005