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Accurate and efficient empirical model generation techniques of microwave devices, for a large range of geometric and material parameters opportunely chosen, are presented. The empirical models are based on multiple linear regression approach, which compensates the error between an initial inaccurate empirical model and an electromagnetic (EM) full-wave solver (or measurement data). The aim of these techniques is to generate accurate empirical models, which are computationally very efficient with respect to any EM technique. These simple models could be integrated in a toolbox of any commercially available computed-aided design tools for RF/microwave circuits. Comparisons with artificial neural networks and linear-regression-based models are listed and discussed for the dispersion of a microstrip transmission line propagating the quasi-TEM mode and a microwave tunable phase shifter propagating the even mode.