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A novel 3D facial animation model is proposed in this paper to generate realistic facial animation sequence. The 3D facial animation model is constructed based on morphable model and compatible with MPEG-4. Uniform mesh resampling method is put forward to align prototypic 3D faces and facial animation principle defined in MPEG-4 is adopted to drive the 3D facial animation model. The animation model can automatically reconstruct realistic 3D face of specific person given a single image and be driven by FAP parameters to generate 3D facial animation sequence automatically. Experimental results show the 3D facial animation model proposed in this paper can effectively generate high realistic facial animation sequence automatically.