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The consecutive hurricane attacks to US coastline have drawn significant attentions to evacuation operations related issues. To better prepare the state of Maryland for potential hurricanes, this study presents an emergency evacuation system that integrates both optimization and microscopic simulation methods. The optimization module applies a two-level process to generate the preliminary optimal control plans, which is based on a revised cell transmission formulation for large-scale network applications. Using the optimized results as the initial input, the simulation module takes into account various operational constraints and driver responses that are difficult to be captured realistically with mathematical formulations. The proposed system also features its flexibility for potential users to adjust the optimized plans in both the planning phase and real-time operations based on the results of simulation evaluation. The case study with the data from Ocean City, Maryland during hurricane attacks has demonstrated the potential of the proposed system for evacuation of traffic flows in large-scale networks within a given time window.