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This paper examines the role of cytoskeletons, such as stress fibers, on magnetic orientation of Schwann cells after strong magnetic field exposure (8-T in maximum). Schwann cells were cultured from dissected sciatic nerves of neonatal rats. Schwann cells oriented parallel to the magnetic field after 60 h of more than 4-T magnetic field exposure. Actin fibers oriented in the direction of the magnetic field after 60 h of 8-T magnetic field exposure but randomly oriented without magnetic field. Orientation of Schwann cells was not observed by inhibiting stress fiber formation using Y-27632, an inhibitor of small guanosine triphosphatases (GTPase) Rho-associated kinase. Our results indicate that the magnetic field elicits reorientation of actin fibers through Rho kinase to allow a response to magnetic orientation of Schwann cells.