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Optimal H insulin injection control for blood glucose regulation in diabetic patients

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4 Author(s)
Chee, F. ; Sch. of Electr., Univ. of Western Australia, Crawley, WA, Australia ; Savkin, A.V. ; Fernando, T.L. ; Nahavandi, S.

The theory of H optimal control has the feature of minimizing the worst-case gain of an unknown disturbance input. When appropriately modified, the theory can be used to design a "switching" controller that can be applied to insulin injection for blood glucose (BG) regulation. The "switching" controller is defined by a collection of basic insulin rates and a rule that switches the insulin rates from one value to another. The rule employed an estimation of BG from noisy measurements, and the subsequent optimization of a performance index that involves the solution of a "jump" Riccati differential equation and a discrete-time dynamic programming equation. With an appropriate patient model, simulation studies have shown that the controller could correct BG deviation using clinically acceptable insulin delivery rates.

Published in:

Biomedical Engineering, IEEE Transactions on  (Volume:52 ,  Issue: 10 )

Date of Publication:

Oct. 2005

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