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This article gives a brief tutorial on transform-domain communication system (TDCS), OFDM, and MC-CDMA. The primary goal of this article is to give a detailed description of the TDCS transmitter and receiver systems and to highlight the fundamental differences relative to OFDM and MC-CDMA. The fundamental idea in TDCS is to synthesize a smart adaptive waveform to avoid interference at the transmitter instead of the more traditional mitigating of interference at the receiver. Unlike OFDM and MC-CDMA, TDCS has very little exposure in the current literature.