By Topic

Biopsy preparation for flow analysis using microfabricated disaggregation blades

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$33 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

5 Author(s)
A. K. Miller ; Dept. of Electr. Eng., Washington Univ., Seattle, WA, USA ; M. L. Stanton ; C. A. Sanchez ; Xiaohong Li
more authors

An epithelial tissue biopsy processor that produces stained cell nuclei as its output using microfabricated disaggregation structures is presented. Stained cell nuclei produced by the processor can be used for a variety of diagnostic tests to assess the presence of cancer or the risk of developing cancer in the future. To better understand the biopsy disaggregation process, biopsies prepared by a highly skilled technician were examined using fluorescence microscopy at various stages of the disaggregation process. Quantitative analysis of nuclei preparations were performed using flow cytometry of the end product. General device architecture, microfabricated glass blade tissue mincing structures, manual disaggregation microscopy evaluation results, DNA content flow cytometry results, and plans for further device development are presented.

Published in:

IEEE International Conference on Automation Science and Engineering, 2005.

Date of Conference:

1-2 Aug. 2005