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This paper is devoted to the coded MC-CDMA (or OFCDM) uplink radio mobile system study. It highlights that the iterative PIC detector outperforms the MUD-MMSE detector when combining with the proposed channel estimation technique. The channel estimation is based on the delay profile algorithm considering the improved path indexes in the frequency domain and on the enhanced polynomial interpolation in the time domain. The proposed scheme is considered iteratively with the pilot and the decoded feedback data. The simulation results show that an important performance improvement is obtained.