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Cross-layer design breaks away from traditional network design where each layer of the protocol stack operates independently. We explore the potential synergies of exchanging information between different layers to support real-time video streaming. In this new approach information is exchanged between different layers of the protocol stack, and end-to-end performance is optimized by adapting to this information at each protocol layer. We discuss key parameters used in the cross-layer information exchange along with the associated cross-layer adaptation. Substantial performance gains through this cross-layer design are demonstrated for video streaming.