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H.264/AVC will be an essential component in emerging wireless video applications thanks to its excellent compression efficiency and network-friendly design. However, a video coding standard itself is only one component within the application and transmission environment. Its effectiveness strongly depends on the selection of appropriate modes and parameters at the encoder, at the decoder, as well as in the network. In this paper we introduce the features of the H.264/AVC coding standard that make it suitable for wireless video applications, including features for error resilience, bit rate adaptation, integration into packet networks, interoperability, and buffering considerations. Modern wireless networks provide many different means to adapt quality of service, such as forward error correction methods on different layers and end-to-end or link layer retransmission protocols. The applicability of all these encoding and network features depends on application constraints, such as the maximum tolerable delay, the possibility of online encoding, and the availability of feedback and cross-layer information. We discuss the use of different coding and transport related features for different applications, namely video telephony, video conferencing, video streaming, download-and-play, and video broadcasting. Guidelines for the selection of appropriate video coding tools, video encoder and decoder settings, as well as transport and network parameters are provided and justified. References to relevant research publications and standardization contributions are given.