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Fabrication and characteristics of bioFET albumin sensor using new self-assembled monolayer

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6 Author(s)
K. Y. Park ; Sch. of Electr. Eng. & Comput. Sci., Kyungpook Nat. Univ., Daegu, South Korea ; K. M. Park ; Y. S. Cho ; S. Y. Choi
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The BioFET albumin sensor with the gold gate as a gate material was fabricated and its characteristics were investigated. To enable label-free molecular detection, the BioFET gate surface was chemically modified by new immobilized molecular receptors, so called self-assembled monolayer (SAM) synthesized by a thiazole benzo crown ether ethylamine (TBECA)-thioctic acid to bind albumin-antibody. In this paper an albumin antigen-antibody binding generated above the gate surface was used as an albumin sensing mechanism of the BioFET. So the drain current was varied by antigen-antibody interactions on gate surface because the albumins have a negative charge. Experimental results related to the formation of SAM, antibody, and antigen were obtained from quartz crystal microbalance and surface plasmon resonance.

Published in:

The 13th International Conference on Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05.  (Volume:2 )

Date of Conference:

5-9 June 2005