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This paper reports a microfluidic chip integrated with molecular imprinting polymers (MIP) for surface plasmon resonance (SPR) detection of specific label-free bio-samples. The innovative microfluidic biochip is capable of transporting a specific amount of bio-samples inside multiple microchannels using micropumps/micro valves to sensing regions where multiple MIP films are locally deposited such that highly-sensitive, highly-specific bio-sensing could be achieved. With the help of SPR sensing techniques, the microfluidic biochips have the potential to be widely used for bio-sensing applications. While compared to other sensing techniques, the developed system has several advantages, including labeling-free, high sensitivity, capability of quantitative analysis of nano-scale bio-molecules in real-time fashion.