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Detection of protein conformational changes with a nanogap biosensor

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5 Author(s)
Nevill, J.T. ; Dept. of Bioeng., California Univ., Berkeley, CA, USA ; Di Carlo, D. ; Liu, P. ; Jeong, K.H.
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We demonstrate for the first time the detection of a conformational change in protein structure using a nanogap biosensor. Understanding the relationship between protein structure and function is paramount to unlocking life's processes on a molecular scale, and it is important to develop efficient measurement tools necessary to record these relationships. We have developed a unique nanoscale electrode-based biosensor that uses dielectric spectroscopy to interrogate samples inside a nanoscale gap, and we have shown that this biosensor is sensitive enough to record the conformational changes of a well known protein.

Published in:

Solid-State Sensors, Actuators and Microsystems, 2005. Digest of Technical Papers. TRANSDUCERS '05. The 13th International Conference on  (Volume:2 )

Date of Conference:

5-9 June 2005