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This paper presents a miniature device for intratumoral delivery of oligonucleotides (ASO). A PZT plate (1 cm2 × 0.75mm) is used to transfect cells using cavitation-induced sonoporation. Both human umbilical vein endothelial cells (HUVEC) and human prostate cancer cells (PC3) are investigated in vitro. Preliminary results show that after cavitation-induced sonoporation, the transfection rate for HUVEC increases by 10% compared to controls (p<0.01). For PC3, the transfection rate increases by 7% compared to controls (p<0.01).
Date of Conference: 5-9 June 2005