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We report on the multichannel IC (RX64DTH) designed for position sensitive X-ray measurements with silicon strip detectors and dedicated to medical imaging applications. This integrated circuit has a binary readout architecture with a double threshold allowing on selection energy window for measured signals. The design was realized in a 0.8 μm CMOS process. The core of the RX64DTH IC consists of 64 readout channels. The single channel is built with four basic blocks: charge sensitive preamplifier, shaper, two independent discriminators, and two independent 20-bit counters. Each readout channel counts pulses which are above the low discriminator threshold and counts pulses independently above the high discriminator threshold. The energy resolution in such architecture is limited by the noise of a single channel and by channel to channel threshold spread. We present the noise and matching performance of a 384-channel module built with a silicon strip detector and six RX64DTH ICs. In the 384-channel module an equivalent noise charge of about 200 el. rms is achieved for the shaper peaking time of 0.8 μs and strip capacitance of 3 pF. The deviation of discriminator thresholds for the whole system is only 87 el. rms. The obtained results show that the energy resolution and uniformity of analog parameters (noise, gain, offset) are sufficient for medical diagnostic applications such as dual energy mammography and angiography.