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In this paper we investigate the impact of wireless opportunistic scheduling on TCP throughput. Considering interference of the adjacent layers, we propose a new ACK reservoir method to smooth the TCP behavior combating the spurious timeout caused by scheduling. Based on performance analysis and simulation results, the proposed method is shown to improve the TCP throughput by up to 100% in the presence of opportunistic scheduling. Finally, the proposed method is evaluated in a practical simulation scenario of CDMA/HDR system.