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In this paper, a micro-genetic based approach to the optimization of reactive power and voltage profiles improvement and real power loss minimization is presented. The reactive power control devices such as generators, tap positions of on-load tap changer of transformers, shunt reactors are used to correct voltage limits violations while simultaneously reducing the system real power losses. Genetic algorithms (GAs) are well-known global search techniques anchored on the mechanisms of natural selection and genetics. Because of the time intensive nature of the conventional GA, the micro-GA is proposed as a more time efficient alternative. The feasibility and effectiveness of the developed algorithm is tested and verified on the Nigerian grid power system for three case studies scenarios preset in the power world simulator. The far-reaching simulation results that validate the effectiveness of the developed tool are presented and discussed in depth.