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This paper introduces the needs of information interoperability on advanced network-based applications-grid computing. The grid has emerged as an important new field, distinguished from conventional distributed computing by its focus on large-scale resource sharing, innovative application, and, in some cases, high-performance orientation. The paper describes the concepts of information-flow theory and using them to support information interoperability in the grid. It presents the layered model for an agent-based information interoperability system. It shows that the integration of agent technology and ontology can improve the automatic process of information interoperability.