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Pulse modulation CMOS image sensor for bio-fluorescence imaging applications

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5 Author(s)
J. Ohta ; Graduate Sch. of Mater. Sci., Ikoma, Japan ; T. Tokuda ; K. Kagawa ; M. Nunoshita
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For wide dynamic range, compatibility with digital circuits, and low-voltage operation, the pulse modulation technique is suitable for an implanted bioimage sensor. We demonstrate bio-fluorescence imaging of the hippocampus in a sliced mouse brain using a pulse modulation-based image sensor. The sensor architecture and system configuration are discussed. In addition, we develop an imaging device for implantation into a mouse brain in order to measure the neural activity in the hippocampus. The device is composed of a pulse modulation image sensor with 128×128 pixels and a fiber illuminator on a polyimide substrate.

Published in:

2005 IEEE International Symposium on Circuits and Systems

Date of Conference:

23-26 May 2005