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Surface modification of superparamagnetic iron oxide nanoparticles for clinical applications

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2 Author(s)
Woo, K. ; Nano-Materials Res. Center, Korea Inst. of Sci. & Technol., Seoul, South Korea ; Hong, J.

Monodisperse superparamagnetic iron oxide nanoparticles (SPIONs) were prepared by thermal decomposition of Fe(CO)5 and by consecutive aeration in organic medium. The resultant hydrophobic SPION surface was modified to be hydrophilic via Fe-S covalent bond with bi-functional mercaptopropionic acid (MPA, HSCH2CH2COOH) and then, the terminal carboxylic acid group was esterified with dextran for biocompatibility. Analysis by water dispersity, TEM, XRD, and FT-IR is discussed.

Published in:

Magnetics Conference, 2005. INTERMAG Asia 2005. Digests of the IEEE International

Date of Conference:

4-8 April 2005