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In this letter, a new orthogonal frequency-division multiplexing (OFDM) technique for multiple-input multiple output (MIMO) channels is proposed to reduce interchannel interference (ICI) caused by high-speed mobiles in cellular environments. After analyzing the ICI caused by high-speed mobile channels using a simple curve fitting technique, the weighting factor for group transmission is optimized. Then, a new MIMO-OFDM technique, based on the weighting factor optimization, is proposed for reducing ICI caused by time-varying channels. Performances of the proposed technique are verified by using the I-METRA channel, proposed for an MIMO channel to 3GPP, and a MIMO-OFDM simulator designed for macrocellular mobile communication. It is shown by computer simulation that the proposed MIMO-OFDM technique is effective in reducing ICI and noise as well as in obtaining diversity gain even under highly-correlated fast fading channels, compared with the conventional MIMO-OFDM schemes.