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Real-time, man-in-the-loop simulation has served an important function in the NASA manned-space-flight program by providing the means to evaluate systems design and integrated systems performance on the ground in a simulated flight environment. The Space Shuttle Program has relied heavily on simulation throughout all phases of development and into Space Shuttle operations. The simulation facilities in the NASA Lyndon B. Johnson Space Center (JSC) Engineering Directorate used in support of Space Shuttle development and operations have been upgraded throughout the 16-year program and reflect near current technology in both computer systems and simulation software design. Operations of the JSC engineering simulation facility, the Systems Engineering Simulator, were expanded in 1985 to support Orbiter-related Space Station design activities such as Orbiter docking scenarios and the use of the Orbiter remote manipulator system in Space Station berthing scenarios. Development of a new Space Station simulation designed to provide long-term support to the Space Station Program is well under way. A description of the two Engineering Directorate simulation facilities, the Systems Engineering Simulator and the Shuttle Avionics Integration Laboratory, is presented. The function of each in support of the Space Shuttle Program is discussed, with emphasis on functions applicable to Space Station. The function of the Systems Engineering Simulator in Space Station development is described. Finally, a comprehensive and detailed description of the new Space Station simulation under development on the System Engineering Simulator is presented.