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Multiprocessor system-on-chip (MP-SoC) platforms are emerging as an important trend for SoC design. Power and wire design constraints are forcing the adoption of new design methodologies for system-on-chip (SoC), namely, those that incorporate modularity and explicit parallelism. To enable these MP-SoC platforms, researchers have recently pursued scaleable communication-centric interconnect fabrics, such as networks-on-chip (NoC), which possess many features that are particularly attractive for these. These communication-centric interconnect fabrics are characterized by different trade-offs with regard to latency, throughput, energy dissipation, and silicon area requirements. In this paper, we develop a consistent and meaningful evaluation methodology to compare the performance and characteristics of a variety of NoC architectures. We also explore design trade-offs that characterize the NoC approach and obtain comparative results for a number of common NoC topologies. To the best of our knowledge, this is the first effort in characterizing different NoC architectures with respect to their performance and design trade-offs. To further illustrate our evaluation methodology, we map a typical multiprocessing platform to different NoC interconnect architectures and show how the system performance is affected by these design trade-offs.