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PRIME is an acronym for a subject-oriented computer-based information storage and retrieval system which uses variable length, variable content, natural language, data collection forms. PRIME was developed as a model of a hospital automated information system and has been in operation since March 1965. Experience with this model system has shown that it is important to spend time planning the management and use of the computer system before the system is installed. Education programs for medical staff members and researchers are well worth the effort because it does take effort to get professional staff members to use a computer system. Data collection forms should be designed by the individual who uses them. It helps him to organize his thoughts about his project. Some conclusions about the administrative aspects of an automated information system in a hospital are presented.