By Topic

Synaptic physiology

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

Formats Non-Member Member
$31 $13
Learn how you can qualify for the best price for this item!
Become an IEEE Member or Subscribe to
IEEE Xplore for exclusive pricing!
close button

puzzle piece

IEEE membership options for an individual and IEEE Xplore subscriptions for an organization offer the most affordable access to essential journal articles, conference papers, standards, eBooks, and eLearning courses.

Learn more about:

IEEE membership

IEEE Xplore subscriptions

1 Author(s)
Stevens, C.F. ; University of Washington School of Medicine, Seattle, Wash.

The sequence of events from axon terminal depolarization to integration of information by summation of separate synaptic effects is described. Following depolarization of the terminal, transmitter substance is released probabilistically in integral multiples of a basic quantity, the transmitter unit. The average rate of unit release depends upon membrane potential, ion concentrations (particularly calcium) in the bathing medium, the quantity of transmitter available for release, and the history of synaptic use. After diffusing across the synaptic cleft, transmitter molecules interact with receptor sites on the postsynaptic membrane and cause the conductance for certain ions to increase; meanwhile, the transmitter is destroyed enzymatically or lost from the vicinity of the postsynaptic membrane by diffusion. The effects from the simultaneous action of many synapses add--often linearly--to permit information from many sources to be combined in a single neuron.

Published in:

Proceedings of the IEEE  (Volume:56 ,  Issue: 6 )