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Method of biochemical patterning which allows for micro- and nano-scale resolution on nonplanar substrates is presented. Utilizing this method, bio-molecules (including DNA, proteins, and enzymes) can be delivered to charged locations on surfaces by charged water buffer droplets. Charging of water droplets is accomplished using dielectric barrier discharge (DBD) plasma. DBD was effectively stabilized in the presence of high concentration of micron-size water droplets. The concepts of the proposed method, as well as first experimental results supporting the idea are discussed in this paper.