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Since the end of the cold war and the fall of the Berlin wall, large scientific projects, such as the LHC and ITER, are now based on international collaborations involving most world powers. These collaborations cover not only the design, but also run the construction and operation phases. Scientists, like other cultural and economical actors, have to adapt and organize their work in this new world environment. They also need to learn how to convince public opinion, offering information and transparency. There is no good model yet on how to do that in the most efficient way and a great deal might be learned by looking at experiences outside the scientific field. Relying on my experience as founder of "Doctors Without Borders" and "Doctors of the World", as well as holder of several ministerial positions in different French governments and as former Head of the UN Interim Administration Mission in Kosovo, I share with you my view on globalization and on how to initiate and carry out large international, nonprofit technology programs.