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A model of the pacemaking neuron of the respiratory central pattern generator

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4 Author(s)
Amini, B. ; Dept. of Neurobiol. & Anatomy, Univ. of Texas Health Sci. Center, Houston, TX, USA ; Bidani, A. ; Zwischenberger, J.B. ; Clark, J.W.

We have developed a model of the mammalian respiratory central pattern generator (rCPG) to mimic the salient characteristics of its constituent medullary neurons. This model is designed as a network of Hodgkin-Huxley-type medullary neurons driven by a pacemaking neuron from the pre-Bötzinger complex. Here, we present the results of our model of this pacemaking neuron, based on available voltage clamp data. Implications for the behavior of the rCPG are discussed.

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Neural Systems and Rehabilitation Engineering, IEEE Transactions on  (Volume:13 ,  Issue: 2 )