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Due to the diffusion of ubiquitous computing environments, the need for adaptive applications to effectively support knowledge sharing, and improve context awareness without interfering with habitual work practices has gained importance. This paper presents the design of an application architecture that exploits an ontology-based knowledge management framework and a reflective middleware to support multi-channel applications. The development of the middleware is carried on in parallel with the development of a real application, SWIRLS, that aims to support the work in a hospital setting. SWIRLS is a case study with real technology and organizational problems that involves innovative devices, seamless interaction via different channels and domain-dependent knowledge management issues.