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The goal of developing advanced diagnostic architectures is to provide a computing infrastructure that can support integration of open, modular software components that maximize reuse of not only static local data but results of dynamic information processing at other nodes in the network-centric architecture as well. Emerging technologies in the support system environment address the development, integration and maturation of complex software systems. This paper will discuss approaches to semantic interoperability that enable the construction of interoperable applications in support of integrated diagnostics objectives. It will investigate existing computing infrastructure constructs that provide support for these goals, as well as current attempts to provide standardized approaches to semantic interoperability.