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This study contributes to a discussion on collaboration and technical/professional communication in indeterminate zones or less familiar sites for collaboration. The interdisciplinary group for this case study collaborated to write a project proposal to solicit funds from the US government for constructing a test bed for immune buildings as a tactic for combating potential biological and chemical terrorist incidents. Their approach to collaboration coincided with several approaches previously addressed in professional and technical communication research. Novel and creative approaches emerged as a result of this collaboration, but in some instances, disciplinary differences, as manifested by disputes over concepts and terminologies, posed obstacles to collaboration. Such challenges necessitated strong leadership, which was also critical for managing group process.