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A new scheme for denoising magnetic resonance spectroscopy (MRS) signals is presented. This scheme is based on projecting noisy MRS signals in different domains, consecutively, and performing noise filtering operations in these domains. The domains are chosen such that the noise portion, which is inseparable from the desired signal in one domain, is separable in the other. A set of stable, linear, time-frequency (SLTF) transforms with different resolutions was selected for these projections as an example. Scheme evaluation was performed using extensive MRS signals with various noise levels. Compared with one domain denoising, it was observed that the proposed scheme gives superior results that compensate for the excess computational requirements. The proposed scheme supersedes also the wavelet packet denoising schemes.