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This paper describes the investigation into the effects of signal cables on the operating frequencies, radiation patterns, and gains of handset antennas under test by using a proposed testing scheme. In this simple testing method, a coaxial signal cable feeds the handset antenna under test through a microstrip transmission-line etched onto a printed circuit board. The studies of the influences of different feeding schemes and cable arrangements on two commonly used handset antennas are carried out experimentally and numerically. Also, the distributions of the fields close to the antenna, handset chassis, and the cable are measured and simulated to explore the cable-related influences.