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An immune algorithm solution is proposed in this paper to deal with the problem of optimal coordination of local physically based controllers in order to preserve or retain mid and long term voltage stability. A multi-stage coordinated control scheme is presented, aiming at retaining good voltage levels with minimal control efforts and costs after severe disturbances in power systems. A self-pattern-recognized vaccination procedure is developed to transfer effective heuristic information into the new generation of solution candidates to speed up the convergence of the search procedure to global optima. An example of four bus power system case study is investigated to show the effectiveness and efficiency of the proposed algorithm, compared with several existing approaches such as differential dynamic programming and tree-search. The proposed algorithm also provides a framework for coordinated control of generic complex systems whose behaviors are influenced by nonlinearity, large-scale, uncertainty and hybrid nature.