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Wide dynamic range pulse modulation image sensor for on-chip bioimaging applications

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6 Author(s)
Tokuda, T. ; Graduate Sch. of Mater. Sci., Nara Inst. of Sci. & Technol., Japan ; Ng, D.C. ; Okamoto, H. ; Kagawa, K.
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Image sensors with a pulse modulation measurement scheme are fabricated for bioimaging and biosensing applications. We designed pulse modulation photosensors and a 64×64-pixel image sensor. We demonstrated the feasibility of the pulse modulation measurement scheme for biosensing applications. We obtained a dynamic range of 120 dB and minimum sensing intensity level of 2 nW/cm2. We also confirmed that 0.2% of intensity change is detectable at the minimum intensity region. An in-vitro, on-chip imaging of a mouse hippocampus was successfully demonstrated.

Published in:

Sensors, 2004. Proceedings of IEEE

Date of Conference:

24-27 Oct. 2004

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