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In order to gain the high quality wireless communication transmission services, we necessarily eliminate multiple-access interference (MAI) that affects CDMA systems receivers. However, the developed MMSE space-time multiuser detection usually needs more complexity computation in receivers. In this paper, we propose an adaptive MMSE space-time multiuser detector, which adopt the Lagrange multipliers method and extend the constraint space. Simulation results show that the scheme can improve the performance of systems effectively.