Scheduled System Maintenance:
Some services will be unavailable Sunday, March 29th through Monday, March 30th. We apologize for the inconvenience.
By Topic

Development of a real-time algorithm for predicting sufentanil plasma levels during cardiopulmonary-bypass surgery, using a systems approach

Sign In

Cookies must be enabled to login.After enabling cookies , please use refresh or reload or ctrl+f5 on the browser for the login options.

The purchase and pricing options are temporarily unavailable. Please try again later.
5 Author(s)
Liu, M.-Z. ; Westchester County Med. Center, Valhalla, NY, USA ; Silvern, D.A. ; Gupte, P.M. ; Inchiosa, M.A., Jr.
more authors

A report on the development of a model for the computer-guided administration of sufentanil throughout surgical procedures involving cardiopulmonary-bypass (CB) is presented. The authors approach the effects of hypothermia on sufentanil clearance by applying a continuous temperature correction to the ultimate elimination rate constant (the terminal eigenvalue). This correction is based primarily on the anticipated effects of temperature on the enzyme-catalyzed reactions which are essential for the elimination of the drug from the body. An algorithm for the application of the model is also presented.

Published in:

Biomedical Engineering, IEEE Transactions on  (Volume:39 ,  Issue: 6 )