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Development of a real-time algorithm for predicting sufentanil plasma levels during cardiopulmonary-bypass surgery, using a systems approach

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5 Author(s)
Liu, M.-Z. ; Westchester County Med. Center, Valhalla, NY, USA ; Silvern, D.A. ; Gupte, P.M. ; Inchiosa, M.A., Jr.
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A report on the development of a model for the computer-guided administration of sufentanil throughout surgical procedures involving cardiopulmonary-bypass (CB) is presented. The authors approach the effects of hypothermia on sufentanil clearance by applying a continuous temperature correction to the ultimate elimination rate constant (the terminal eigenvalue). This correction is based primarily on the anticipated effects of temperature on the enzyme-catalyzed reactions which are essential for the elimination of the drug from the body. An algorithm for the application of the model is also presented.

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Biomedical Engineering, IEEE Transactions on  (Volume:39 ,  Issue: 6 )